[feniv]

As a python programmer, these were the first two settings I configured after installing Sublime Text.

    "tab_size": 2,
    "translate_tabs_to_spaces": true

You can either set them as Preferences > Settings - Default or Settings - Syntax specific

[natrius]

Uh, two space indentation in Python? Consistency is valuable. Everyone else who writes Python uses four spaces.

http://www.python.org/dev/peps/pep-0008/#indentation

[tass]

This is a great reason to use tabs over spaces.

[buttscicles]

It wouldn't matter when people don't adhere to standards anyway.

[ketralnis]

That everybody else uses spaces?

[yen223]

If the file uses tabs, at least you can choose to display the indentations as 2 spaces or 4 spaces.

If the file uses spaces, you don't get to choose.

[SquareWheel]

This is my reason for preferring tabs. Plus changing indent levels is faster via arrow keys.

[Tloewald]

The main reason for preferring spaces is wrapping complex calls split across lines. (Of which there is a lot in some languages such as obj-c or JavaScript.) We just went through the whole tabs vs spaces debate on a new project here with, I think, open minds and a general preference for tabs, and ended up using spaces. The alternative was tabs for basic indentation and spaces for line wrapping but that's too hard to maintain.

YMMV

[kstrauser]

And even faster using tab or shift+tab to pop up or down a level, regardless of whether you're using tabs or spaces.

[charliesome]

Any reasonable editor can be configured to jump multiple spaces at a time.

[feniv]

I got comfortable with 2 spaces over 4-space tab since it was the accepted coding standard for Ruby at my previous job. The habit carried over to Python and I now find it more succinct and clear.