The best-reasoned criticism of glyphosate is that it disrupts the gut biome (this is a fact). I suspect that many "gluten allergies" are actually gut biome problems from glyphosate-desiccated wheat.
Anything that reaches the gut intact disrupts (ie: manipulates, interacts with, alters, stimulates or suppresses, selects) the gut biome. I'm not pushing back on you except to say that as a mechanistic axiomatic claim of harm, it's missing most of the evidence. You could be right, but you could also be wrong; what you've said so far can't possibly be dispositive.
The mechanism of action of glyphosate inhibits several important amino acid production processes in the gut. I'm simplifying here, but not having glyphosate in the food supply would be a good thing for the gut, and the science agrees on this.
Glyphosate for field prep also doesn't really come through in food, it's much worse with the pre-harvest desiccation.
You are inferring from our crude understanding of processes in general. Evidence is more specific.
Do you have an exclusion trial comparing glyphosate vs non-glyphosate diets? This is amenable to natural experiments where one country bans it on a specific date and the neighbor does not.
Here's a decent one: 13% of the UK reports gluten intolerance symptoms, and only 7% of Germany does. The UK allows pre-harvest glyphosate desiccation, Germany doesn't. I would be happy to bet that the trend continues past my quick Google search.
> Do you have an exclusion trial comparing glyphosate vs non-glyphosate diets?
That's a rather sneaky way to invert the issue. It's fishing for random luck when you ask for more and harder to obtain evidence given existing facts pointing to possible harm. A single study that doesn't show harm doesn't refute those that do.
You have to provide hard evidence that glyphosate (or another non-essential ingredient) does not cause adverse effects, and thoroughly explain the differences with the studies that show the opposite - until you do that, any in-vitro or other studies that show harmful effects count against the use of the product and you cannot ask for more evidence, you can only accept the remedies.
In this case, the appropriate remedies can be different: banning it altogether, limiting it to specific usage (e.g. no pre-harvest spraying), labeling using LARGE PRINT and scary language or some combination of the above.
You can't even get smoked fish accepted through precautionary-principle logic like that. This is the same reasoning that puts cancer warnings on bags of potato chips.
> You can't even get smoked fish accepted through precautionary-principle logic like that.
No, you really can't do that without breaking the Code of Federal Regulations. Smoked products must be labeled "smoked" in addition to many other requirements, and that despite the distinctive stink that self-labels these products. Even the font size is specified to be no smaller than the letters for the kind of meat on the label.
The real issue is why there's no such requirement for glyphosate, having it would be a good starting point.
> This is the same reasoning that puts cancer warnings on bags of potato chips.
I don't think all potato chips deserve, or have, such warnings but some might. Regardless, there might be specific regulations that are over the top and I don't mind admitting or discussing such cases but glyphosate isn't among them.
Smoked fish is a side, wheat is a staple. Degree matters.
If 90% of the raw food at the grocery were 'processed' in the same way that a smoked fish, or a french fry was, I think we'd have very valid reasons to be displeased with many of the myriad problems that come with that.
"Glyphosate complexation to aluminium(III). An equilibrium and structural study in solution using potentiometry, multinuclear NMR, ATR–FTIR, ESI-MS and DFT calculations"
AFAIK the preponderance of the evidence is that most "gluten sensitivity" is actually just a FODMAP sensitivity, which also interacts with the gut biome.
The Wikipedia page for it is pretty good. Basically, there are a number of short-chain carbohydrates that tend to pass through the small intestine (where nutrients are digested and absorbed into the bloodstream) and reach the large intestine (where water is removed). Bacteria in the large intestine eat these nutrients (fermentation). In some people, this causes intestinal distress. (Bloating, gas, discomfort, watery stool, etc.) It's not clear why this only affects some people.
You hear a lot about it because a large subset of people have discovered that a low-FODMAP diet relieves their torment of intestinal distress.
FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. FODMAPs generate gas as side effect of being fermented in the gut. Most people just pass this gas, but for some people, usually people with irritable bowel syndrome (IBS), it can be very uncomfortable and amplify their other IBS problems.
People who are suffering from pain and bloating with no obvious cause may be advised to go on a low-FODMAP diet for a few weeks to see if their symptoms go away.
I will never understand this bizarre obsession with gut flora. We don't know what is normal, what is a beneficial ratio or when a change happens if that is good or bad thing. No one besides the people who study these things should be much attention to gut microbiomes. We just don't have enough information to let this be an influence on decision making.
Your comment seems a little flippant honestly. I know what "disrupted" is, trust me. I developed a gluten sensitivity about 10 years ago but only figured it out 5 years ago. "Healthy" is "feels healthy" and "doesn't die young", that is pretty simple.
It sounds like you think this is about hypothetical and marginal health benefits but people have very acute and immediate physical (and cognitive) issues because of disrupted gut biome that are objectively improved by cutting out, in particular, gluten. This isn't just some weird obession.
Gluten intolerance is a real thing but I don't think that necessarily means that your gut flora is damaged or whatever. Plenty of people are lactose intolerant, and their gut flora is fine, they're just lactose intolerant.
I don't think you could solve gluten intolerance but just improving your gut microbiome, so they're probably not related.
Why are you narrowly focusing on gluten intolerance when this line of comments appears to be denying whether gut biome is worth caring about due to having impacts on health?
> Could be FODMAP + IBS or maybe some other sensitivity.
Seems extremely unlikely. Of someone is eliminating gluten they from their diet they usually aren't also eliminating dairy, legumes, and other high-fodmap foods; gluten-free is restrictive enough already.
The only other sensitivity I could think of in which this makes sense is wheat sensitivity (but not other gluten containing grains which are less common).
By itself, it's simply an argument that proves too much. Anything you ingest impacts your gut flora. There can be gut microbiome hypos about glyphosate! But you have to actually have them; you can't stop at "it impacts gut flora".
Well, I didn't intend that as a conversation-ender, but it is true. This particular substance inhibits a particular function of certain gut flora that seems important. I think it's safe to call that significant.
What "particular function" is that? If it's "the part that influences neurological function", you don't have a complete argument. If you can't be specific about this, your argument falls apart, because almost everything we eat potentially "inhibits" (or accelerates) different areas of our gut flora.
I'm not trying to make a complete argument, I'm trying to raise a flag. This issue is not well-studied and has very large corporate sponsors who would like to keep selling Roundup-Ready™ crops. One particular measurable function is inhibition of the shikamate pathway in many different bacteria (the majority of the volume of your gut flora is affected).
I understand that this is the realm of crunchy weirdos, but thinking holistically doesn't mean you need to lobotomize yourself.
Here's another paper examining some brain effects of chronic gut inflammation, which could be reasonably inferred as a potential consequence of long-term glyphosate exposure: https://pmc.ncbi.nlm.nih.gov/articles/PMC10661239/
“I don’t understand it well enough in my opinion so we shouldn’t care about it”?
I’m pretty sure there’s hundreds of things we rightly understood are detrimental centuries before we knew how it worked. Aka pretty much everything bad before 1900.
Changing your diet disrupts the gut biome. When I started eating bran flakes it massively disrupted my gut biome. Should I be alarmed? Or are you slipping a double standard in there, perhaps from the naturalistic fallacy?
Maybe you should see if you adjust to the bran flakes, cut them out if you don't improve, and see if there's a difference? All sorts of things can disrupt gut biomes, and I think ancestral diets are an interesting area of study. Gut inflammation is absolutely rampant.
People who have gluten allergies have a legitimate disease, typically celiac disease.
Being tired after eating bread or whatever is not a gluten allergy, that's just how food works. A lot of people claim to have gluten allergies but no, you would know for sure if you had a gluten allergy.