[saadn92]

This is similar to what we see in software architecture. There's a team that picks a framework or pattern early, then builds everything on top of it, and by the time evidence shows up that the foundation was wrong. Now, switching costs are so high that it's cheaper to keep building on the broken foundation than to start over. The amyloid hypothesis reminds me of technical debt. The "cabal" wasn't conspiring, but they were just rationally protecting their sunk costs, same as any engineering org that can't migrate off a bad database choice.