[ch4s3]

> discovered through gradual process of elimination that she gets migraines from MSG

This is definitely not true. There is no biological pathway that can do this. MSG is nearly identical to the glutamic acid in other foods. If it were true they'd be unable to tolerate parmesan cheese, soy sauce, aged meats, tomatoes, mushrooms, and seaweed.

[cestith]

Glutamate is considered a migraine trigger, though. Many people do avoid or limit those foods for that reason. Thankfully it doesn’t appear to be a trigger for me, because I love all those things.

There is some controversy about dietary glutamate being directly responsible for migraine. It’s common in the brain already. It’s only allowed selectively through the blood-brain barrier. However it could trigger other types of headache, and those can trigger migraines. Also, apparently more of it is formed in the brain when there are high levels of lysine and ornithine in the body. Many of the foods with high levels of glutamate also have high levels of those aminos.

High levels or low levels of sodium in the body can also be a migraine trigger. MSG is lower in sodium than table salt, but it is additional sodium. Many of the issues blamed on it though are after eating foods that contain MSG and a high amount of salt as well. That’s also true of many of the glutamate-containing foods for that matter (gravies, miso, soy sauce, aged meats).

Doctors recommend eliminating one single ingredient at a time to find your triggers. However, I’m sure many people don’t control for salt when eliminating MSG or natural food glutamate.

[ch4s3]

Elevated brain glutamate levels are associated with migraines, but there’s no solid evidence that dietary glutamate is a trigger for migraines.

The number of people avoiding it is not evidence of anything other than public perception.

Elimination diets are also super impressive.

[cestith]

I agree on all your points. If someone suffers from migraines, though, it’s worth trying figuring out plausible triggers even if the evidence isn’t really solid.

It’s important not to conflate ingredients when doing an elimination diet, though. Separating restaurants or prepackaged foods at home that use MSG from those that use a lot of salt (or preservatives, or artificial dyes, or “natural flavors”, or any number of other things) is pretty difficult. I’ve seen several instances over the years of people assuming a restaurant used MSG based on getting a migraine, even when that restaurant doesn’t use MSG in any of their dishes. I’m not even a doctor, just an interested person with migraines. I’m sure a nutritionist or headache specialist could tell us stories.

[ch4s3]

There's a pretty good finding here[1] about elimination diets being inappropriate for most patients. Basically without any diagnosis of something like celiac, allergy, etc you have a high risk of misidentifying foods as causes because the co-occur with non food triggers. The literature just seems super weak for most alleged dietary triggers.

[1]https://pmc.ncbi.nlm.nih.gov/articles/PMC12609589/#sec8-nutr...

[bennettnate5]

> This is definitely not true. There is no biological pathway that can do this

Nevertheless, it continues to give her migraines even in small portions where other foods don't. I don't doubt it could be some byproduct from the process of MSG salt's synthesis or cooking with it rather than the actual glutamic acid, or some allergy as others have suggested.

I wouldn't be so strong as to categorically say that MSG can't cause migraines in any of the human race as you so claim though. There's so much we don't know about human biological mechanisms in niche cases; even water can cause allergic reactions in certain individuals (see Aquagenic Urticaria). What is true generally is not always true specifically when it comes to human health.

[bruckie]

I'm curious: have you done a (single or double) blind test where you prepare dishes (selected at random) with or without MSG/aspartame/yeast extract and record the effects?

To be clear: not saying you should, just wondering how you came the conclusion that those ingredients are the trigger.

[neonstatic]

Why are you arguing when the internet expert already stated that is impossible.

[dekhn]

MSG is the salt form, wherre the glutamate is bound to a sodium atom. In food, my understanding is that MSG will split into two things: sodium ion and glutamate ion. The difference between adding MSG to food and food being already high in glutamate would be the salt content.

I don't recommend telling people their subjective experience isn't true- you don't know for sure that they don't actually get migraines from MSG. I think it's fine to tell people that often their subjective experiences can be colored by prior knowledge, and people often ascribe causes to unrelated factors. (My personal belief is that most people who say they got a headache from MSG experienced a headache, but consuming glutamate was not the cause).

[cyberax]

For some people, migraines can be triggered by things like light or certain smells. It's not at all impossible that a certain taste can also trigger them.

[srean]

That's very interesting because cheese, paneer and cured meats do trigger wife's migraines. I had not considered that richness is n glutamic acid is a common factor.

The personal, anecdotal relation seems strong on the cheese and paneer component. Even if she had something not aware that it contains either of those it would trigger a migraine, sometimes not immediately though, seems to take a few to several hours.

Will have to try a blind testing with MSG.

[human_person]

Oh she/you should check out mast cell activation syndrome (mcas). Basically different foods increase histamine levels in the body or prevent its degradation. Old proteins and fermented foods are particularly problematic because microbes break down the protein and release histamine precursors.

[srean]

Thanks for the suggestion.

[eszed]

Well, my dad got migraines from everything° on that list bar tomatoes - though he did from dried tomatoes, so does that count as everything on the list? I don't know the biological pathway, but it was neither self-diagnosed, self-derived, nor made from woo; he visited several real-MD neurologists before someone identified the chemical(s) at fault, and gave him a list of foods not to eat.

°In fact it was all cheeses, not just parmesan; the more aged the worse. And also chocolate, and olives. Basically anything aged or fermented. I don't know how that lines up with MSG's chemistry, but he was careful with MSG, though nothing like as avoidant as he was with soy sauce and cheese.

[BobaFloutist]

Migraines are complicated enough that I'd buy a psychosomatic trigger, maybe?

[cestith]

Migraines can possibly be triggered by cause and effect chains several intermediate causes long. It could help explain for example why certain things are triggers for certain migraine patients and not others.