[cxr]

> This paper has presented a study of a system that provides code generation and continuous code optimization as a central system service[…]

> Our results have shown that–because of the profiling feedback loop–object code produced by continuous optimizations is often of a higher quality than can be achieved using static "off-line" compilation. Optimization at runtime, if performed judiciously, can often surpass optimizations performed at compile-time, independent of whether the latter are guided by profiling information or not. Our results have also given evidence that reoptimizing an already running program in response to changes in user behavior can give rise to real performance improvements.

Kistler, Thomas, and Michael Franz. "Continuous program optimization: Design and evaluation." IEEE Transactions on Computers 50, no. 6 (2002). <https://doi.org/10.1109/12.931893>