[diogenes_atx]

Scattered throughout this discussion are a number of comments concerning the potential damage to the stomach lining from ibuprofen, naproxen and aspirin. This is an important consideration when choosing a painkiller. According to a recent Washington Post article by Trisha Pasricha, MD, "You should avoid taking nonsteroidal anti-inflammatory drugs, or NSAIDs — such as ibuprofen, naproxen and aspirin — whenever possible. If you do need to take them, use the smallest dose for the shortest time feasible."

Dr. Pasricha adds: "I don’t get too concerned if my patients take one or two doses every now and then. But through regular use, such as several times a month or more, NSAIDs are well-known to increase intestinal permeability. In other words, NSAIDs can damage the lining of our guts. That’s because NSAIDs reduce the blood flow in the tiny vessels feeding our guts and disrupt the intestinal cells forming a barrier between the outside world and your insides. This has been proven over and over again through decades of research."

Conclusion: Acetaminophen is generally safer than ibuprofen, naproxen and aspirin.

https://www.washingtonpost.com/wellness/2024/12/09/ibuprofen...

https://archive.is/XRZEU

[squidbang]

Anecdotal, but this is what got me to finally see a doctor about purpose-made migraine abortives. I was taking huge doses of naproxen multiple times a week, until I started to get terrible heartburn with every dose.