[gus_massa]

The immune system destroy all the DNA in unexpected places in case it's a https://en.wikipedia.org/wiki/Viroid or something. Better safe than sorry.

One of the important steps in mRNA vaccines was to surround the mRNA with a lipid to ensure it can survive long enough to enter a cell. Naked mRNA would not have worked.

[etiam]

One has to wonder whether destroy is all it does though. Analyzing this as cues about the surroundings seems like it could be pretty useful for successful living, and something evolution could well pick up on. Will we find eventually that some of those nucleic acid fragments were being hauled off for identification in something like an extra inner sense of smell?

[cwmoore]

No need to wonder if you study the lymphatic system.

[gus_massa]

> No need to wonder if you study the lymphatic system.

Does it mean yes or no? I think "no", but IANAMD; IANAB, ... I think it only identify proteins, glycoproteins, and other stuff that is in the surface of the cells/virus but not the DNA/RNA.

[etiam]

Maybe so, but also maybe not quite my point, unless you know something I don't about it.

Sure, some samples will be off to antigen presentation, but does that inform more than this is an encountered foreign substance and this is how to bind to it for neutralization ? Seems like in principle you could take the overview picture and have something like olfaction, but for things that hadn't been sufficiently cracked open when they passed the olfactory epithelium. Maybe it's starting to be sorted out, but I'm not up to date on what the neural feedback from the immune system carries.

[SiempreViernes]

If the quantities are too low for the nose to pick them up I think nature has converged on "too noisy to bother with".

[etiam]

Are the quantities too small though? Really foul-smelling small molecules can be sensed at least down to ppb concentrations. And the recent technical use of "eDNA" demonstrates there's signal to be had.

[throe939rjdor]

Not just rna, but dna as well.