[bodiekane]

Cycling has a pretty rich history of people injecting themselves with things they bought on the internet- EPO, testosterone, etc.

The bodybuilding subculture has been injecting testosterone, about 50 different testosterone-like drugs (Tren, Clen, Deca, etc) for the past 50 years, HGH for the past 30 years and IGF for the past 15 years.

The psychonaut subculture has been buying research chemical derivatives of serotonin and dopamine for decades for their psychedelic effects, and the nootropic community doing similar things for compounds that increased attention, memory or mood.

In prior decades, the transgender community often relied on buying & injecting drugs on the internet for gender affirming care they were unable to get from their healthcare systems.

There are risks, but also, if tens, hundreds or thousands of other customers have purchased and used something from the vendor, that's probably as reliable of a signal as most regulatory regimes are.