[cthalupa]

> But they are ineffective outside clinical trial setting for treating obesity.

This is one of the wildest claims I have ever seen on this website.

Would you claim insulin is ineffective outside of clinical trials for treating type 1 diabetes because people have to keep injecting it?

[rzmmm]

I hope it sounds less wild if you think obesity as disease of addiction. Reducing GLP1 dose can increase the enjoyment in eating, so it makes sense why treating obesity with GLP1 is like treating alcoholism with disulfiram: Effective in theory but hard to adhere outside trials.

Type 1 diabetes (or majority of diseases) doesn't involve addiction.