[watermelon0]

There is a recent one, which shows that the weight was generally stable after 1 year of discontinuation of GLP-1.

> In this cohort study of adults with overweight or obesity who initiated treatment with injectable semaglutide or tirzepatide and discontinued the index medication between 3 and 12 months after initiation, 19.6% restarted the index medication and 35.2% received an alternative treatment in the year after initial treatment discontinuation. The average weight change 1 year after index medication discontinuation was relatively small; however, there was considerable individual-level variability.

https://dom-pubs.pericles-prod.literatumonline.com/doi/10.11...

[gpt5]

Thanks for sharing. Note that the data quality from this study is quite low because 54.8% of the cohort eventually restarted their medication or transitioned to an alternative therapy (mostly a different weight loss medication).

I don't know why a study that focuses on discontinuation didn't split the groups that restarted or transitioned against the group that actually just stopped.