[ErroneousBosh]

It doesn't reduce heart attack and stroke. It reduces appetite, kind of, and gives you a sore stomach while making you shit yourself inside out. All this can, with care, help contribute to weight loss.

Weight loss can reduce heart attack and stroke, but GLP-1 does not.

You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

[cthalupa]

We see risk reduction for heart attack and stroke for people on GLP-1s even without weight loss, which belies the idea that the protection only comes from losing weight.

Edit: In fact, from the study -

BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),

Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted

NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted

BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)

[ErroneousBosh]

Have you got a link to the study those figures are actually from? I'm not saying their wrong but I would like to read and understand them for myself before I change my mind.

> BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),

So, what, was 35.86 the BMI at the start, 34.57 the BMI when they stopped taking the drug, and 35.48 after some interval?

For someone of a fairly average height, say 1.86 metres (that's a little under how tall I am) a BMI of 35.86 would be 124kg which is ridiculously fat and 34.57 would be around 119.6kg so you're looking at a loss of around 4.5kg or so.

That's a good shit and a haircut, in the grand scheme of things. It's fairly normal for someone's weight to fluctuate by a kilo up or down (a range of 2kg over normal) and not utterly off the map for a range of four kilos on a day-to-day basis, especially in obese people. That's why you're not supposed to keep weighing yourself and obsessing over the weight.

[rootusrootus]

What is it about GLP1s that bring out the kooks who suddenly think diet and exercise are the only valid medical treatment? Is it a moral issue?

[sublinear]

Unless we're talking about emergency care, most pharmaceuticals are completely unnecessary and carry serious risks.

There's not a single qualified doctor out there that would promote drugs before preventative measures.

[cthalupa]

Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue.

Saying they should try this first at this point in the game is like having your support case escalated 5 times already and them saying "have you tried turning it off and on again"

[ErroneousBosh]

> Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue.

If it's not working for you, it may be because you haven't sorted the "diet" bit.

Are you eating "low fat" or "low calorie" things? Because those are not food and they will make you fat.

Eat food, just a bit less of it than you do now.

[cthalupa]

Obviously the calories in are greater than the calories out if the diet doesn't work.

That's not the point.

The point is the vast majority of overweight and obese people try to diet and do not succeed in it.

[cthalupa]

As best as I can tell, people are very attached to having achieved their body weight through whatever means they have determined are valid and derive self value from it, and believe that GLP-1s are cheating to achieve a result they worked harder for.

[array_key_first]

Yes, it's a moral issue.

What you need to understand is there are a lot of people where all they have is being skinny and appearing to be healthy. Without that, there's nothing left for them.

For a long time, there has been a moat that they can use as a justification for why they're better. They can say "well I work hard, I eat right, I put in effort!" The idea that others can achieve that without any of that means... well, they did it all for nothing. In their heads.

The dirty little secret? Many of them don't do any of that, it's just a delusion. Always has been. I'm skinny, you think I go to the gym? Fuck no! I should, but I don't. And I eat whatever I want.

But if a lot of people have to face the reality that their most redeeming quality is nothing of their doing, that would ruin them. Ruin them. They could just, like, get achievements or something but that's hard. Continuing the delusion is easy.

[malfist]

Your comment is all kinds of wrong.

A) it does have cardio protective effects.

It does reduce your appetite, and for most people have very few side effects. If you get nausea you're titrating up too fast. Most people, because it slows gastric emptying, it doesn't make them shit themselves "inside and out". GLP1s are a decent option for treating ibs-d or bile acid issues and is better tolerated than your bile acid sequesterants.

> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

This victim blaming advice has been given for decades and obesity rates have been climbing for decades. Only glp-1s have reduced that.

[shlant]

> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

Oh wow it's so simple! why has nobody thought of this before??

[ErroneousBosh]

You've been being told this your whole life.

You still think mass-marketed "low fat" foods are good for you.

You still think you can pop a pill to make your problems go away.