[nabbed]

I can't speak specifically about Peter Thiel, but I get the impression that two things affect some extremely wealthy people later in life regardless of their intelligence or benignity: 1) they get encapsulated in a bubble, and 2) they run out of things to achieve, so their obsessions start to become more and more odd. As to number 2, it's almost like those telomeres that keep the integrity of DNA, where every time a cell divides, the telomere gets shorter and shorter, until the cell gets weird.

[10xDev]

No just chronic sleep deprivation. <6 hours sleep a day catches up to you and the effects can be very severe.