[tomhoward]

I wasn't referring to cholesterol, lifestyle, diabetes, etc - or at least not only those things.

I'm talking about any condition at all that diminishes one's health condition from being "perfect" - regardless of whether the cause is genetic or something else. Some of these can currently be understood and diagnosed (but usually aren't), whilst others may become understood, diagnosable and curable in the future.

To me, hypertrophic cardiomyopathy would disqualify someone from being described as having "perfect health".

BTW, this is interesting: http://med.stanford.edu/ism/2010/june/hypertrophy.html - and it includes a mention of epigenetics, which I think is highly relevant to what we're talking about.