[panzagl]

> More and more promising treatments are accumulating in the pipeline, fueled by an explosion of new therapeutic modalities, ranging from mRNA to better peptides and more recently, by AI.

If the pipeline is backed up you put a bigger pipe in place, not get rid of it and hope some of the resulting flood goes where you want.

[peyton]

It’s less of a pipeline and more like a rocket engine. The exhaust gas (clinical data) spins the pump. We’ve put restrictors on that flow, and it’s taking a lot of fuel to get off the ground.

[estearum]

> The exhaust gas (clinical data) spins the pump

Not really. Real-world data is used very heavily already and is far less helpful than we'd hope for in drug development.

It's much more like a pipeline.

[panzagl]

Rockets with unrestricted flow are called bombs.

[terminalshort]

They're called solid fuel rockets