I don't mind Scheme - love it. But MMIX is one heck of a convoluted, "fantasy-alien" assembly language that I cannot stand. Gave up reading TAOCP because of it. Knuth should have stuck to pseudo-code or plain C.
Not sure if that's sarcasm or not, but when I was in uni (late 90s), it was C++, which was very much a practical real-world language. There was a bit of JavaScript and web stuff, but not much (but Javascript was only 4 years old when I was a senior, so...).