[Nursie]

Yeah I've done that, I used my linux box for years with a 24" 1920x1200 screen and a 32" 4k screen next to each other.

Doing some basic mathematics and xrandr command-line wizardry to apply scaling factors to each display, I was able to get Xorg to render to a virtual framebuffer and treat the monitors as appropriately scaled windows onto it, so that dragging applications from one screen to the other didn't result in any noticeable change in size.

Worked pretty well.