[jcranmer]

AIUI, all such results are because the FDA has given up since aduhelm and said "well, if it clears amyloid, that's as good as slowing Alzheimer's, right?" despite the actual results on Alzheimer's progression being largely negative.

[riskassessment]

For what it's worth, early statins were originally cleared based only on the evidence that they lower cholesterol without longer term studies showing a reduction in mortality. Of course there is now plenty of evidence showing statins improve overall endpoints.

[Auracle]

That’s true.

Similarly, there were other drugs that lowered cholesterol that didn’t show a significant reduction in coronary events. As we later learned, it’s not nearly as simple as “cholesterol bad.”

[simulator5g]

That doesn't sound like the same thing at all.