[Aurornis]

Both alcohol and marijuana have direct actions on the brain. That’s why people consume them.

They do not exert their primary effects via microbiome modulation. This is obvious because the effects occur nearly immediately upon consumption, whereas microbiome change from what you consume is a gradual process.

The question I have is: Why has microbiome become the explanation for everything? What would lead you to believe that microbiome would be the explanation for this, when the direct action upon the brain is so much more direct and obvious? Microbiome is an interesting area of research but how did we get to this point where some are ignoring the obvious and trying to construct alternative microbiome based explanations for things like alcohol and marijuana impairing memory?

[coldtea]

>Both alcohol and marijuana have direct actions on the brain. That’s why people consume them.

Which is orthogonal as to whether those direct actions also affect long term memory.

>They do not exert their primary effects via microbiome modulation.

Who said anything about primary effects?

[metalman]

a great deal of alcohol, weed, etc, is consumed ,very specifcly, to forget. to the point that users, often workers doing labour, or other jobby jobs, get fairly aggetated by days, and especialy weeks end, wrapped up in an overload of the realities of serving others interests, and ends. drugs provide a crude function similar to the processing that occurs durring sleep and dreaming. That this has effects on the gut, is hardly unexpected ,but that the system will recover with due care, is. Treating the gut as a self maintaining biological digester, which it is, then suggests looking at how various industrial digestors operate and malfunction.