[pulvinar]

In System Settings > Keyboard Shortcuts > App Shortcuts, add the shortcut: app Safari, name "Quit Safari", command-option-Q. This will leave command-Q doing nothing, yet still allow you to quit. Repeat for other apps.

[eviks]

That's a lot of work to do it per app! And remember to do for every new app

[voltaireodactyl]

FWIW you can do it for “all apps” in one go — I set one up for printing to PDF and it works great

[eviks]

You can't do that because the design of the whole system is dumb - instead of matching by unique (within the app) universal (=across apps) menu item id like "quit" that's hardcoded into the framework, you must match by menu item displayed name "quit Safari", which is different for every "quit MyNewShinyApp"

PS: and sometimes the name string is also dynamic "Navigate to the latest folder named XYZ", so you can't match at all!

[joeframbach]

Nah, I installed karabiner and set up command+q to require a three-second holddown to activate.