[mattip]

CFFI is fast on PyPy. The JIT still cannot peer into the compiled C/C++ code, but it can generate efficient interface code since there is a dedicated _cffi_backend module built into PyPy. Originally that was the motivation for the PyPy developers to create CFFI.

[glkindlmann]

Thank you for the background info, and sorry for me explaining CFFI (I just wanted to be sure we were talking about the same thing). Being ignorant about PyPy, I honestly had no idea until now that there was a personnel or purpose overlap between CFFI and PyPy. I am very grateful for CFFI (though I only use it API mode).