[bob1029]

The human body has a fairly elegant regulation mechanism for handling variance in things like CO2:

https://en.wikipedia.org/wiki/Bohr_effect

I think regular exercise can help to offset some of the effects of rising CO2 levels. Clearly not an end game solution but it's something to consider because you do have control over this one.

[OutOfHere]

A rise in blood bicarbonate, even if in the normal range, particularly at the upper end of normal, is still dangerous at times. The problem is that it has an effect of diminishing extracellular potassium which leads to spikes in heart rate, risking a cardiac emergency. I have witnessed it first hand.