[randlet]

I use WingIDE's[1] professional version (which includes the editor source code) and it has the ability to highlight a section and evaluate it either in the REPL or at the current breakpoint in a debug probe.

It also has decent vi and emacs keybinding support, really nice interactive debugger (including template debugging for Django) and great intellisense. It's the best Python IDE I have found, the support is great and I have been a very happy customer for three years now. (I was using emacs for everything before).

[1]http://wingware.com/

[thronemonkey]

Do you know if it supports ipython? I'm on the scientific computing side of the python world, so django is less important to me . . .

[randlet]

It does not unfortunately. You can do interactive matplotlib plotting but it doesn't behave in the same "shell + REPL" way that ipython does.