[dakolli]

Not everything can be understood through p values and studies with 13 PARTICIPANTS undergoing a ONLY TWO EXPERIMENTS each, nor should the observed effects on 13 PEOPLE (half placebo) be extrapolated out to justifying safety for hundreds of millions of people. Next time you want to prove a point, take the time to research good sources, and not just ask an llm use your brain for once.

Please go put your kid on amphetamines for 15 years and let me know how that works out for them..

Do you care how much incidents of psychosis it causes on a yearly basis?

I said that the Ruling class (aka these professors) are pushing an agenda, and then you choose to provide evidence published by the ruling class to support that agenda.

[cluckindan]

You did understand that the parent post was referring to the referenced articles within the linked article?

14: https://journals.sagepub.com/doi/10.1177/1087054711427299 - N=50

54: https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.12917 - N=82

55: https://www.sciencedirect.com/science/article/abs/pii/S01497... - review of 21 studies

[dakolli]

Often prescribed to treat attention-deficit/hyperactivity disorder, the risk was highest in those taking 30 mg or more of dextroamphetamine (which corresponds to 40 mg of Adderall),

The researchers identified 1,374 cases of individuals presenting with first-episode psychosis or mania, compared to 2,748 control patients with a psychiatric hospitalization for other conditions like depression or anxiety. They conducted a comparison analysis of stimulant use over the preceding month and accounted for other factors, including substance use, in order to isolate the effects of stimulants.

They found the attributable risk percentage among those exposed to any prescription amphetamine was nearly 63 percent and for high dose amphetamine was 81 percent. These findings suggest that among people who take prescription amphetamine, 81 percent of cases of psychosis or mania could have been eliminated if they were not on the high dose. While a significant dose-related risk increase was seen in patients taking high doses of amphetamine, no significant risk increase was seen with methylphenidate (Ritalin) use, which is consistent with previous research, including a 2019 study led by Moran.

https://news.harvard.edu/gazette/story/2024/09/high-doses-of...

Among 1,374 case subjects and 2,748 control subjects, the odds of psychosis and mania were increased for individuals with past-month prescription amphetamine use compared with no use (adjusted odds ratio=2.68, 95% CI=1.90–3.77). A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

I don't care, the drug isn't safe. I've seen it permanently change many people. I don't care if they handpicked <100 individuals to prove safety. The doses cited above >40mg are pretty typical.

[mapontosevenths]

Should we also outlaw penicillin because a tiny percentage of people who take too much have negative side effects?

Also the linked Harvard article points out that "no significant risk increase was seen with methylphenidate (Ritalin)".

It isnt stimulants in general, just Adderall, and just when you take too much.

[dgacmu]

Your own quote literally states that methylphenidate didn't appear to cause any of these problems.

Q: what's the most widely prescribed ADHD medication?

A: Ritalin / Methylphenidate

> Methylphenidate remained the most widely prescribed drug, although the use of lisdexamfetamine and guanfacine has expanded in recent years.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12565614/

It's almost like ... you work with your doctor to identify an effective treatment that balances the costs and benefits for your particular situation.

This applies to most medicines and it's why we have a set of people trained to navigate those tradeoffs. You seem focused only on the negatives of ADHD meds, which are real, without acknowledging that for some patients there are large benefits too. That seems kind of myopic.

[brailsafe]

I think your take is a bit alarmist, if I were to be generous. On one hand, ya it's a pharmaceutical empire, but on the other, that empire's conduct is as detrimental to the people that actually do need those medications as they are to the people that might not. Nobody should be forcing their kids to take anything, but if a kid is struggling, it should be an accessible option, and it will probably help them get by in a system not designed for them. There's no reason to suggest that the general case is that a parent or some company is force feeding their kid meth.

I'm one of those people that could have benefited from it MUCH earlier, it's also incredibly boring if you get the right one. I have no idea what they really do for people who don't have ADHD, but for me it basically lets me get places on time and have a passably productive day. It's also not that trivial to get depending on where you live, and potentially expensive.

> Please go put your kid on amphetamines for 15 years and let me know how that works out for them..

Please tell someone who's gone from having 7 jobs in 7 years to 1 job for 3 years that they don't need it.

We can have issues with the implementation, that's fine

[dakolli]

Well I'm glad you haven't had any major side effects, just know you're playing Russian roulette with your sanity, and the way you perceive reality.. I'm not exaggerating here, give it a decade..or don't

And you're kind of confirming my original thesis, that its a class of drugs created by the ruling class for the working class to make the best workers for capital/ruling class, which it seems to have accomplished that in your case...

Among 1,374 case subjects and 2,748 control subjects, the odds of psychosis and mania were increased for individuals with past-month prescription amphetamine use compared with no use (adjusted odds ratio=2.68, 95% CI=1.90–3.77). A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

[fragmede]

> high doses of amphetamines (>30 mg dextroamphetamine equivalents)

If you do a harmful amount of something, it harms you. Seems pretty straightforwards. To vilify the whole concept seems a bit much though.

[brailsafe]

> And you're kind of confirming my original thesis, that its a class of drugs created by the ruling class for the working class to make the best workers for capital/ruling class, which it seems to have accomplished that in your case...

I don't take amphetamine specifically, methylphenidate, which seems to have no pronounced influence on the apparently correlation based study outcome. Taking these drugs however is not something I approach lightly, but it's also not something I do for anyone else. If anything, it helps me maintain my own adult life. The job is an incidental but important factor.

[toast0]

I've heard anecdotal reports from many people with ADHD symptoms that stimulants (caffiene, ritalin, street drugs) do help them focus. And quite a few from people with ADHD symptoms that stimulants make things much worse. And there's also reports that the stimulants help with focus but cause other problems.

If you're using chemical interventions for ADHD symptoms, you've got to be evaluating the response as well as getting feedback from the patient. Starting with small doses when possible is probably advisable.

Many symptoms can be addressed by behavioral and environmental/situational changes rather than chemical intervention, but chemical interventions can be effective for many, even if they're not effective for all.

[dakolli]

stimulants help everyone focus if dosed correctly!! I never said that it doesn't have that effect. I'm just arguing its very bad for the brain, and it mostly just benefits your employer/future employer at the risk of you going literally insane. Its a tool for Empire/Capital. Its very common for Empires to dose their working class on stimulants to achieve certain goals. It may help you but you're also risk of getting amphetamine induced psychosis, which should void any potential gain for any reasonable person..

[OkayPhysicist]

"Mostly benefits your employer" my ass. ADHD isn't just "ugh, I don't like doing my job". Things you want to do, or need to do, even enjoy doing, and fully intend to do end up constantly pushed to the side when you're unmedicated. You end getting into difficult situations because you've managed to procrastinate taking the 10 minutes it takes to renew your car's registration for 6 months. You struggle to maintain relationships, both friendly and romantic, because people interpret your inability to focus on them as disinterest. You lose sleep, and not just a little, because you lay in bed and simply cannot focus on going to sleep long to actually do so. So you stay up until completely exhausted, but guess what? That doesn't align with anybody else's schedule.

Then you take a pill, and all of these problems just disappear. If you want to work out, you can just go to the gym and work out. No weird little ritualistic hacks, just "I want to do X, I shall do X". You receive a wedding invitation, and you can just spend the 10 minutes making travel arrangements, rather than procrastinating it for months. You can see that a load of laundry needs to be done, and just spend the 5 minutes loading the washing machine, rather than having to push past your brain screaming like you're trying to stick pins in your eye.

[antonvs]

> stimulants help everyone focus if dosed correctly!!

The science contradicts that. You need to re-read my original comment and its references and respond more seriously, if you're genuinely interested in the topic.