[wongarsu]

To add another data point, a 2024 study [1] on the mental effects of single doses of creatine was using 0.35g/kg of creatinemonohydrate, or about 28g for a typical adult male. Though obviously high doses are safer if you just do them once

And an earlier 2018 article [2] argued that "Evidence suggests that the blood–brain barrier is an obstacle for circulating cre- atine, which may require larger doses and/or longer protocols to increase brain creatine as compared to muscle. In fact, the broad spectrum of creatine sup plementation studies that span different dosing pr- tocols (e.g. high-dose short-term, low dose longer- term), co-ingestion of other nutrients/compounds (e.g. carbohydrate, protein, insulin), different popu lations (e.g. vegetarians, elderly, patients, athletes) is unavailable for brain creatine adaptations"

1: https://www.nature.com/articles/s41598-024-54249-9

2: https://www.researchgate.net/profile/Bruno-Gualano/publicati...