Hacker News new | ask | show | jobs
by colechristensen 131 days ago
I have heard a few very different experiences with GLP-1s, for some an almost magical relief from addictive behaviors, for others they didn't notice much on that front at all.
4 comments

So much is about what is causing the behavior I would expect. GLP-1s don't change the way you think so much as breaking some of the trigger mechanisms.

Are you doing the action because you want to do it, or because your body is responding to that mild trigger that occurs, but your pavlonian response is so strong you can't differentiate.

The thing is, those trigger mechanisms break after weeks without doing them, whereas it is very hard to break them normally without some more extreme measure.

this is baseless speculation.

there are GLP-1 receptors on neurons, the drugs cross the blood-brain barrier, they are active in reward centers.

these drugs directly affect the behavior of neurons, it's not some chain of effects that result in behavior change

Which is common with any medication and why medicine is so hard. Two people can react wildly different to the same drug.
Without getting into individual physical differences that occur, expectation is a huge part of addiction and overcoming addiction. Rituals are very often a part of substance abuse for similar reasons. It sounds silly, but consciously placebo-ing yourself can be very effective for people trying to quit. "This medicine will cure my addiction" can be a very powerful mantra for people with a strong imagination.
ah, nope. not everything is just a placebo.

I've heard very addictive personalities describe it as a light switch being turned off, people who have been on a whole host of different things across time.

Individual differences in medication response isn't just placebo.

Why make medicine at all if essentially you think you just have to convince people of fairy stories well enough for literally anything to work?

I'm in the latter group. I've had little to no weight loss from Ozempic because my issue is having a sweet tooth, not eating too much regular food. Yeah I fill up faster, but by the time I would fill up on cookies or something that's still a crazy amount of calories. So it hasn't really helped me to curb my weight. It has helped my A1c though, which is the main thing.