| No one knows of course, but it's looking likely -- anecdotal data is piling up. That said, there are some that have reported it also lessens desire for things they want to desire. Did a writeup on this back in summer '25: https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-... Paywalled so direct links to notable papers through the years below: https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504 https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218 https://pubmed.ncbi.nlm.nih.gov/36031011 https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505 https://pubmed.ncbi.nlm.nih.gov/39764175 https://pubmed.ncbi.nlm.nih.gov/39032839/ https://www.science.org/content/article/obesity-drug-cuts-op...
https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei...
(The science.org article is paywalled IIRC) https://pubmed.ncbi.nlm.nih.gov/39535805/ https://pubmed.ncbi.nlm.nih.gov/39937469/ Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points. Eli Lilly has taken to calling GLP1s "anti-hedonics" as well |