[r0ze-at-hn]

> Benjamin, compared muscle stem cells isolated from young and old mice and discovered that a protein called NDRG1 increased dramatically with age—reaching levels 3.5 times higher in old cells than in young cells.

So ERa down-regulates NDRG1 and there is less ERa activation when we age. Evolution is all fun, but before reaching for anything like that we can apply basic knowledge around that path. We can pick a random gene downstream of ERa to get a grant and write a paper on how it is different in people that are older. Years of possible papers to write.