[microtherion]

Right now, I suspect the Uno is easier, because there is so much existing infrastructure around it.

Also, one of the appeals of Arduino to me is to re-learn simplicity, and relying on hardware solutions, due to the limitations of the micro controller. With a µC as powerful as the Due, the temptation for software types like me is to brute force everything in software again, which sort of defeats the purpose of Arduino tinkering for me. I've actually started playing with the ATtiny85, to have an even more limited hardware platform.

However, as a practical device, it looks like the Due is vastly more powerful than the Uno.