[deknos]

they lost it, when they hardwared it with systemd.

Nothing against systemd, but hardwaring is not a good idea in that regard.

With guix, you at least install things in a container.

sadly, guix also went the non-conda-route, so you could not use it as a conda replacement only :(

[forgotpwd16]

Nix is not hard coupled to systemd. There's nixpkgs support for Darwin afterall.