It is. But if you mean .NET WinForms then you don't really need Wine because Wine uses Mono to run .NET executables. If using WPF then you should check out Avalonia UI [1] which is a cross-platform alternative that is also probably better (and has good tooling in VS). There's also .NET MAUI [2] but it's maybe not as good for desktop apps.
[1] https://avaloniaui.net/ [2] https://dotnet.microsoft.com/en-us/apps/maui