[brandonb]

There are multiple independent risk factors for heart disease. The major ones are:

  - LDL / ApoB
  - Blood pressure
  - inflammation (hs-CRP)
  - Insulin resistance (HbA1c)
  - Lp(a): strongest hereditary risk factor.
  - eGFR: a measure of kidney function

Non-statin drugs like PCSK9 inhibitors have been shown to reduce heart attacks, strokes, and other cardiovascular events on top of statin therapy. One randomized control trial was FOURIER in 2017: https://www.nejm.org/doi/full/10.1056/NEJMoa1615664