[deaux]

> validated the functional connectivity findings in a precision imaging drug trial with highly sampled (n = 5, 165–210 min each) healthy adults (methylphenidate 40 mg).

40 mg!? I'm hypersensitive to it, so my ideal dose is about 5-6mg of extended release. First time the doc prescribed 20mg and I took one I was full on jaw-clenching, teeth-grinding like an addict, felt incredibly anxious and just spent an all-around awful three hours. But even for the "normal" people, outside of the US where half the nation is on legalized meth, isn't 40mg considered a high dosage everywhere else in the world? I get that they want things to show up clearly on the scans, but still it seems like dosage here has the potential to impact what gets activated.

[Honga]

While is was taking MPH I'd take 10mg three times a day (male, 76kg). The times I'd taken twice that amount would turn me into a face twisted gargoyle. 40mg would be unpleasant for sure.

I met a couple of doctors at a party once who would take 60mg recreationally each before going dancing. Seemed unreal.

[deaux]

> The times I'd taken twice that amount would turn me into a face twisted gargoyle.

Fantastic way to describe it, saving this one for later use.

[astrange]

Mag glycinate helps with face clenching, but I also couldn't go above 20mg Vyvanse without feeling uncomfortable.