[Aardwolf]

Base 16 (or base 10, as they would call it) is the perfect base: http://www.intuitor.com/hex/

[Skwid]

I'm standing my ground on optimal base, but I will absolutely be using those hex pronounciations in future

[rep_lodsb]

The "dividing things by two" argument makes a lot of sense! And if you need ⅓ and ⅕, they aren't too bad either: .5555 and .3333 repeating.

[nephihaha]

Sexagesimal (Base 60) is the way to go. Plenty of history behind it and can handle much larger numbers than decimal.