[canucker2016]

from the linked drug trial article, https://www.nejm.org/doi/full/10.1056/NEJMoa2500969:

  Gastrointestinal adverse events were more common with oral semaglutide than with placebo (74.0% vs. 42.2%).

That placebo value seems high (42.2%), given it's just a placebo (sugar pill?).

[DANmode]

As someone who almost died of (unrelated) gastroparesis: be absolutely sure you need this drug.

[dpark]

The placebo effect is shockingly strong. 30-50% report subjective benefits with placebo. Makes sense that about the same would report subjective side effects.