[cpeterso]

Firefox's lack of HiDPI support was killing my eyes, but I've been using Nightly builds and they look great. The only problem I see is that Flash plugins get confused about screen sizes (so YouTube has tiny control buttons).

[codemac]

The plugin support hasn't bothered me yet, and it's almost surprising.

The amount of flash I use on a daily basis is so incredibly minimal these days. I've started using the built in plugin blocking with firefox. The only time I really turn it on is for Netflix and the occasional video that isn't part of the HTML5 beta on youtube is about it.

( not that any of this is an excuse to not fix the bug :P )

[mushishi]

As Google Chromes GWT Developer plugin is noticeably slower (and stopped working altogether) than that of Firefox's, having to use non-retina supported browser for GWT development is annoying.

[lukeschlather]

I usually start up a Chrome private browsing tab for Flash stuff, and use Firefox for most other stuff.

[leif]

netflix is silverlight, not flash, though this is tangential to your point