[crote]

That screw hole is just the regular locking USB-C variant, is it not?

See for example:

https://www.startech.com/en-jp/cables/usb31cctlkv50cm

[wlesieutre]

Looks like it! Thanks for pointing this out, I had no idea it was a standard.

Apparently since 2016 https://www.usb.org/sites/default/files/documents/usb_type-c...

So for any permanent Thunderbolt GPU setups, they should really be using this type of cable

[wtallis]

Note that the locking connector OWC uses is a standard, not the standard. This is USB we're dealing with, so they made it messy: the spec defines two different mutually-incompatible locking mechanisms.

[jamiek88]

Of course they do.

[TheJoeMan]

Now that’s one way to enforce not inserting a USB upside-down.