They're not the same. VMs can assume invariants (which may not always hold) and compile specialized methods which depend on those assumptions and then fall back to a non-optimized version during the execution of a method. To do something like that (OSR) in C, you'll have to have a very sophisticated runtime.
Profile-guided optimization is decades old. It was, for example, one of the things people loved about the (Ultrix?) DEC Alpha compiler was profile-driven optimization.
There is a major difference between performing profile-generated optimizations at compile-time based on sample data, and performing it at run-time based on real data. It is one pretty good way in which JITs could beat programs implemented directly in C.