Node-RED is great for IoT/edge/data flows. Sim is built specifically for AI agents—native LLM support, tool-use control, structured outputs, token-level observability, etc.
afaik, there are actually a ton of unique IoT integrations that node-red has. a majority of their nodes/flows have accompanying physical devices and sensors
N8n and its clones are attempts to copy and commercialize it with a closed-source license.