[therealkatie]

If your HTML is valid, and you're not doing crazy stuff with your headers, chances are the screen reader is going to do just fine.

I worked for the government, and every single site we put out had to be 508 compliant (in other words, accessible). It never doubled our budget, ever, and we had some pretty complex interfaces.

As for point two, go check out how many Baby Boomers are alive today. Then, remember this:

Baby boomers control over 80% of personal financial assets and more than half of all consumer spending.

They're also going to start needing sites that deal with their aging eyes, poor vision, and joint issues.

[debacle]

If most of your site is rendered with JavaScript and most of your content is delivered via JSON, you're kind of screwed.