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by kion 199 days ago
retaglutide is the next gen (3rd) GLP-1 which is in phase 3 trials now. It is a triple antagonist (current are dual GLP-1/GIP). It adds glucagon, and apparently that comes with not only greatly increased weightloss, but also wicked sugar cravings.

These things do way way more than just appetite and craving suppression.
1 comments
fragmede 199 days ago
Interesting! how does that work though? I thought reduced sugar craving was part of how GLP-1s aid in weight loss as the paitent craves sugar less and thus eats less.
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kion 199 days ago
I'm not a biochemist, so I can't say with any authority, but presumably its to do with the 3rd antagonist and its impact on glucagon. Most of what I have heard is through Reddit communities for the on-market drugs (1st and 2nd gen peptides). The anecdotes from Retatrutide sound like it has way less impact on appetite and for some people that's actually a downside even though the weight loss effects appears to be significantly more powerful.
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