[arianvanp]

Yes. It's great. Especially paired with nix-darwin which allows you to declaratively manage all your macos settings too

[pasc1878]

Sort of.

For things that run on Linux and other Unices yes.

For macOS UI programs and those that need specific permissions and for commercial programs stick with Homebrew but you can define what you want in homebrew in nix.

[rusty-jules]

Using nix-darwin to manage brew declaratively feels like using a jackhammer to nail a picture to the wall, but I can’t live without it anymore.