| > Here is how we'd do that combination therapy. We'd mix a standard antibiotic with oral para-Aminosalicylic acid (PAS). I responded to your comment above with this same claim. I cannot find any sources that say reducing manganese was the mechanism of PAS in TB. A recent research paper on PAS in TB doesn't even mention manganese once. It identifies Dihydrofolate Reductase related actions as the mechanism against TB: https://pmc.ncbi.nlm.nih.gov/articles/PMC5395024/ > orally delivered PAS is the the standard treatment for treating excess manganese in humans. EDTA has been the standard treatment. PAS has been explored and trialed. It can be used, but I don't know if I'd call it the "standard" treatment. > (Sorry, but you're dead wrong about needing a completely synthetic diet for months.) I was talking about a low-manganese diet, which the comment above me suggested. I don't know why you're so set on calling me "dead wrong" so much when you can't provide sources and aren't even reading what I'm writing. > While PAS does harm a few kinds of stomach bacteria, it is far better than a broad spectrum antibiotic. And if the target disease is under stress already, then you need less antibiotic to finish them off. You're really going to have to provide sources for PAS reducing manganese as a mechanism for fighting TB. As I pointed out in my other comment, manganese is an essential cofactor for one of the other anti-TB drugs in the triple combination that was used in the past. |