[btilly]

That's stupidly wrong.

I regularly find myself on a zero manganese diet for hours at a time, and I've yet to experience immediate death, screaming in agony.

Furthermore we have lots of data on how well humans can tolerate extended low manganese regimens. The standard treatment course for TB in the 1950s resulted in humans having low manganese for 1-2 years. This was unpleasant, but not lethal.

[Aloisius]

Source? I can't find anything about the standard treatment course for TB in the 1950s resulting in low manganese.

[btilly]

See https://pmc.ncbi.nlm.nih.gov/articles/PMC4407437/ to verify that PAS was used.

Any google search on PAS and manganese will show that it eliminates manganese from the body by chelating it, and is therefore used for treating manganese toxicity.

I don't have a specific reference for manganese levels in people undergoing the old TB treatment. But I'm sure that it should exist somewhere.

[Aurornis]

> I don't have a specific reference for manganese levels in people undergoing the old TB treatment. But I'm sure that it should exist somewhere.

You've spread this claim throughout the comment section and called others "dead wrong", yet even you can't find a reference to support it?

The mechanism of PAS in TB is not manganese reduction: https://pmc.ncbi.nlm.nih.gov/articles/PMC5395024/

[Aurornis]

I wrote more above, but I cannot find anything to support this claim about PAS being used because it reduces manganese either.

The mechanism of action of PAS against TB is in the Dihydrofolate Reductase pathway: https://pmc.ncbi.nlm.nih.gov/articles/PMC5395024/

I can only guess that this commenter saw that PAS can also be used for manganese chelation and jumped to conclusions?