[SamuelAdams]

You can run it natively, but it is better to downscale to 4k or 1080p. I run three 5k versions of this monitor and they are all downscaled to 1440p. I get 1:1 pixel mapping so text looks crisp in every app except Microsoft Teams.

[Tepix]

Isn‘t downscaling the wrong term? You‘re still taking advantage of its native resolution.