[nailer]

    get_response().json() 

is ideal, and I'm assuming yoiu're writing an HTTP wrapper since decoding JSON is a sensible default.

If you need to add an intermediary variable, name it as clearly as possible:

    raw_response = get_response()
    response = raw_response.json()

[nomel]

> The fact that the first response is immediately overwritten proves to the reader it's not important/never used, so they can forget about it, where a temp variable would add cognitive load since it might be used later.

I strive to write code that reduces cognitive load. To me, putting it in a temp variable is more of habit of old languages, mixed with a bit of cargo cult.

[nailer]

> To me, putting it in a temp variable is more of habit of old languages

If you do want an intermediate variable, naming it non-deceptively will reduce cognitive load. If you don't want one, that's fine too. There's no deception with a name that doesn't exist.