The complete Framework Desktop with everything working (including said Ryzen AI Max 395+ and 128 GB of RAM) is 2500 EUR. In Europe the DGX Spark listings are at 4000+ EUR.
It's a different animal. Ryzen wins on memory bandwidth and has 'AI' accelerator (my guess matrix multiplication). Spark has times lower bandwidth, but much better and more generic compute. Add to that CUDA ecosystem with libs and tools. I'm not saying Ryzen is bad, actually it's great Mac substitute for poor man. $2K for 128GB version on Amazon now.
Online only at https://frame.work AFAIK. I don't think people shelling out 2-4k for an AI training machine are concerned whether or not they can find it at a hardware store locally or online, but I may be wrong.