[notahacker]

Since the admins aren't in space, actors that want to use administrative privileges to interfere with your data have no less access to it than if the datacentre was located on the ground.

The difference between the US government censoring a datacentre in orbit and one in California is a matter of cost rather than practicality, and it's actually easier for other spacefaring powers to interfere with it in a deniable manner if it's that important to them than the datacentre in California

[nine_k]

This depend on you threat model. If your model is mostly legal threats form less-than-nation-state actors, being formally outside any terrestrial jurisdiction may help. If you try to protect yourself from a big threat that won't mind raiding (or bombing) your DC without a court order, quite possibly locating it in space is not the best idea.