The paper is 10 years old. While the gap between a threaded an interpreter (a dispatch at the end of every handler) versus non-threaded (loop over switch) isn't as big as it used to be, it's still 15-30% on modern very fast interpreters. For example, I measured between 14 and 29% performance improvement for threading Wizard's interpreter[1].
Interesting paper :) I've kept choosing threaded myself, but would have put the gap in a 5-10% range. I guess the branch predictor hasn't kept up. (Also trying to resist getting nerdsniped into measuring it myself 0_0)
[1] https://dl.acm.org/doi/10.1145/3563311