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by groovy2shoes 259 days ago
indeed, finasteride raised my T levels slightly, from 18 ng/dL to 30 ng/dL. the same enzyme that converts T to DHT (5α reductase) can also to convert progesterone to DHT via the backdoor pathway, but i reckon that would have a very small effect for most cis men (where normal progesterone levels range from 0.0-0.5 ng/mL, compared to 2.0-24.0 ng/mL in cis women during the luteal phase, and much higher during pregnancy).

a sudden hormonal change can absolutely cause changes to mood and libido, but with finasteride these seem to be rare and generally mild. i would expect them to lessen or even disappear after some time of continued treatment. i wonder how often finasteride is discontinued before the body even has a chance to adjust to the new hormone levels. the claims that the side effects persist after discontinuation are particularly dubious, and they remind me of castration anxiety.