[neuronic]

Probably a "the dose makes the poison" kind of thing? Constant inflammation and exposure to inflammatory agents could eventually raise the likelihood of cell damage in affected tissues, no?

The immune system is highly highly complicated and directed by huge networks of genes and molecules all up- and downregulating each other depending on internal and external factors. If things go "off balance" in this system the consequences could be dire.

You dont want firefighters hosing down your house from the inside when there is no fire anymore either.

[Workaccount2]

Ever since I had covid 5 years ago, my body has been stuck under a constant firehouse shower. High heart rate, shortness of breath, and a constant pressure in my upper chest.

I know it's immune related, because when I am coming down with a cold the symptoms all vanish. Like the firehose has an actual fire to fight.

[baby]

When you're sick your body releases all sorts of stuff that makes you super relaxed and force you to chill/rest, so might be completely unrelated

[Earw0rm]

Which is in itself odd, as there's no obvious mechanism (at least in a developed nation inhabitant who typically have considerable fat reserves and ready availability of food) for the immune system to need resources which would be otherwise used by the muscles.

Like we can all feel the lack of "energy", but that energy isn't the same thing as actual calories, glycogen, blood O2 and so on. Presumably a lot of CFS conditions are relating to that biological switch - "you're ill, rest up!" - getting stuck in the "on" position, but AFAIK nobody has definitively found it despite a whole lot of looking.